New Hotel OPENING IN May 2021

A New Level of Well-Being, Cleanliness, and Service!

Rewards Category 4 Points needed per night

Among Jacksonville, FL hotels, the brand new Residence Inn Jacksonville - Mayo Clinic Area is uniquely positioned and customer focused, providing a clean and comfortable environment featuring an array of amenities and special care services. Located just 3 minutes to Mayo Clinic, a complimentary shuttle is provided. When you want to explore Jacksonville, we're (3 mi) to Jacksonville Beach, (5 mi) to University of North Florida and only (17 mi) to all of the excitement in Downtown Jacksonville. All of our suites feature a fully equipped kitchen, living area, free WiFi, sofabed, 55" SMART HDTV with Netflix. When looking to relax, take a dip in our outdoor swimming pool or enjoy a beverage and a bite to eat at our lobby bar. Enjoy the benefit of a great workout in our state-of-the art fitness center. Book your next event with us featuring 4,128 sq ft of flexible meeting and outdoor space for up to 180 people. We look forward to serving you and to extending our warm hospitality.

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Key amenities

  • Kitchen/Kitchenette
  • Free high-speed internet
  • Free breakfast
  • Pet friendly


  • Just .6 miles to Mayo Clinic. This all-suite hotel offers free shuttle to the clinic

  • We're experts in Extended Stay hotel visits, our goal is to make you feel at home

  • Meeting and banquet accommodations to accommodate up to 180 people

Now Selling Starting 5/30/2021

Guests can now book starting 5/30/2021 for reservations! Staying longer? Check out our Thrive on Long Stays offer for guests staying 7 or more consecutive nights...get a $25 Target Card for groceries. View Offer

Guest rooms

Relaxing Suites with full kitchens near Mayo Clinic

  • King Studio Suite

    King Studio Suite

    Studio, 1 King, Sofa bed
  • In-Suite Full Kitchen

    One Bedroom Suite

    1 Bedroom 2 room Suite, 2 Queen, Sofa bed
  • King Studio Suite

    King Corner Studio Suite

    Larger Studio, 1 King, Sofa bed, Corner room

Check room rates & availability

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