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The Inn at Mayo Clinic

4420 Mary Brigh Drive  Jacksonville  Florida  32224  USA 

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(proof of eligibility required at check-in)

About special rates and awards

To make reservations by phone, dial freephone 0800 221 222 in the UK, 1 800 409 929 in Ireland, or view our regional telephone reservation numbers.

Local Area

Bask in the sun and enjoy beautiful sunsets from the pier at Jacksonville Beach.

Enjoy a stroll through one of more than thirty local preservation parks.

Be ready to cheer like never before at a Jacksonville Jaguars football game at EverBank Stadium.  


  • Stonewood Grill & Tavern 4.8 km  



    Open for lunch and dinner

    From seafood to beef and chicken to salads, everybody will find a favorite meal at Stonewood.

  • Marker 32 3.2 km  



    Open for lunch and dinner

    Overlooking the Intracostal Waterway Name by Gourmet Magazine as "One of Florida's Most Distinctive Restaurants", this award-winning restaurant is known for its seafood creations, freshly baked breads and seasonal desserts.

  • Outback Steakhouse 4.8 km  



    Open for lunch and dinner

    Great food from down under, with great steaks, chops, shrimp on the "barbee" and Bloomin' Onions.

  • LongHorn Steakhouse 4.8 km  



    Open for lunch and dinner

    A casual, Texas-style setting and reasonably priced steaks makes this one of the area's most popular steakhouses.

  • Dick's Wings & Grill 2.4 km  



    Open for lunch and dinner

    Featuring more than 365 varieties of wings, Dick's has something to please everyone, from mild mannered wings and burgers for the kids, to Cajun ranch hot wings for Dad.


Comprehensive dining guide 




  • World Gym and Fitness Center 3.2 km  


    • Cardiovascular equipment
    • Free weights
    • Basketball, café/smoothie bar, tanning

    Fitness classes: Fee

    Special guest privileges: indoor basketball court; aerobics room




  • Biking trail 0.5 km
  • Bowling 8 km
  • Hiking 20.9 km
  • Horseback riding 8 km
  • Jogging/fitness trail 0.5 km



Jacksonville Beach 8 km


  • California Trends Day Spa & Salon 5.6 km

Family & Children's Activities

  • Jacksonville Beaches 11.3 km
    • Visit the First Coast's great beaches, with lots of dining, shopping and nightlife.
  • Town Center Mall 8 km
    • The area's newest & most talked about shopping, dining & entertainment destination.
  • St. Augustine Premium Outlet Malls 38.6 km
    • Great shopping and great Savings with over 170 stores.
  • Alltel Stadium 19.3 km
    • Home of the Jacksonville Jaguars, University of Florida/University of Georgia game, Gator Bowl.




Bus Station

Train Station


  • Jacksonville International Airport - JAX

    Airport Phone: 1 904 741 4902

    Hotel direction: 43.8 km NW

    This hotel does not provide shuttle service.

    • Alternate transportation: Professional Car Service (Hank Blackstock); fee: 60 USD (one way) ;on request
    • Estimated taxi fare: 60 USD  (one way)

    Visit JAX airport website  

    Follow Airport Road to I-95 South, exit 126A (9A East). Take 9A South to Butler Boulevard east. Take Butler Boulevard east to the San Pablo Road exit. Turn left on San Pablo. Drive .10 mile, turn left into Mayo Clinic entrance. Make first right, hotel will be on your left.

  • Craig Municipal Airport - Jacksonville - CRG

    Airport Phone: 1 904 641 7666

    Hotel direction: 10.5 km NW

    This hotel does not provide shuttle service.

    • Alternate transportation: Professional Car Service; fee: 40 USD (one way) ;on request
    • Estimated taxi fare: 40 USD  (one way)

    Visit CRG airport website  

    Take Atlantic Blvd. East to San Pablo Road. Take a right on San Pablo Road. Cross over Beach Blvd. and take a right on William Davis Parkway. Take the first left and the hotel will be immediately on your right. (on the Mayo Clinic campus)



Complimentary on-site parking


  • Nearby:
    • Hertz  

      1106 3rd Street South

      Jacksonville Beach, Florida 32246

      Phone: 1-904-242-0448

    • Enterprise  

      (use code 43A4664 for a 5% discount)

      Jacksonville Beach, Florida 32250

      Phone: 1-904-249-0805

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The Inn at Mayo Clinic

The Inn at Mayo Clinic The Inn at Mayo Clinic

4420 Mary Brigh Drive

Jacksonville, Florida 32224

Visitor's Guide:Jacksonville  

The Jacksonville Browser

A directory to shopping, dining, attractions and other points around town

Identification of these resources is solely for the convenience of our guests. Neither Marriott International, Inc. nor any of its affiliates or franchisees endorses or is a sponsor of these resources.

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